Effect of test treatments on systemic parameters
| Variable | Baseline | Treatment | Adjusted mean difference formoterol–salbutamol (95% CI)* | p-value | ||
| Formoterol | Salbutamol | Formoterol | Salbutamol | |||
| Eav on SBP mmHg | 134.1 (100–186) | 132.9 (110–169) | 126.5 (98–169) | 124.7 (101–151) | 1.5 (-2.6–5.6) | 0.48 |
| Emax on SBP mmHg | 134.1 (100–186) | 132.9 (110–169) | 135.5 (100–187) | 133.1 (105–169) | 2.1 (-2.9–7.0) | 0.41 |
| Eav on DBP mmHg | 82.1 (60–102) | 79.7 (60–102) | 75.7 (53–93) | 73.4 (49–92) | 1.9 (-1.1–4.9) | 0.21 |
| Emin DBP mmHg | 82.1 (60–102) | 79.7 (60–102) | 68.9 (50–86) | 67.7 (45–91) | 1.0 (-2.5–4.5) | 0.56 |
| Eav on ECG heart rate beats·min−1 | 99.4 (62–137) | 96.3 (67–144) | 93.4 (60–122) | 93.5 (69–128) | -2.0 (-6.5–2.6) | 0.39 |
| Emax on ECG heart rate beats·min−1 | 99.4 (62–137) | 96.3 (67–144) | 102.1 (70–130) | 101.7 (72–137) | -1.6 (-6.5–3.4) | 0.53 |
| Eav on ECG QTc ms | 412.6 (325–505) | 423.3 (338–527) | 409.8 (340–492) | 422.2 (374–496) | -7.9 (-19.4–3.6) | 0.18 |
| Emax ECG QTc ms | 412.6 (325–505) | 423.3 (338–527) | 435.4 (372–554) | 453.2 (394–634) | -13.2 (-29.4–2.9) | 0.11 |
| Eav on S-potassium mmol·L−1 | 3.85 (3.0–4.9) | 3.88 (3.0–4.7) | 3.83 (3.1–4.6) | 3.82 (3.0–4.6) | 0.04 (-0.07–0.16) | 0.44 |
| Emin on S-potassium mmol·L−1 | 3.85 (3.0–4.9) | 3.88 (3.0–4.7) | 3.63 (2.9–4.5) | 3.60 (2.8–4.6) | 0.06 (-0.07–0.18) | 0.35 |
Data are presented as mean (range), unless otherwise stated. *: performed using ANOVA. CI: confidence interval; Eav: average effect between 45 and 240 min; SBP: systolic blood pressure; Emax: maximal effect between 45 and 240 min; DBP: diastolic blood pressure; Emin: minimal effect between 45 and 240 min; ECG: electrocardiogram. 1 mmHg = 0.133 kPa.