Tests | Screening | Baseline | Drug phase I | Drug phase II | |||||
Visit | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 |
Day# | 0 | 14 | 15 | 29 | 43 | 44 | 58 | 72 | 73 |
Spirometry | ¶ | ¶ | ¶ | ¶ | ¶ | ¶ | |||
Methacholine challenge test | ¶ | ||||||||
Plethysmography/closing volume | ¶ | ¶ | ¶ | ||||||
HRCT with methacholine challenge | ¶ | ¶ | ¶ | ||||||
Questionnaires | ¶ | ¶ | ¶ | ¶ | |||||
Diary/peak expiratory flow recording | ¶ | ¶ | ¶ | ¶ | ¶ | ¶ |
HRCT: high-resolution computed tomography. # : assuming a 14-day run-in; ¶: tests performed.