Table. 9—

Summary of the procedures relating to bronchodilator response

Procedures suggested to minimise differences within and between laboratories
 Assess lung function at baseline
 Administer salbutamol in four separate doses of 100 µg through a spacer
 Re-assess lung function after 15 min. If you want to assess the potential benefits of a different bronchodilator, use the same dose and the same route as used in clinical practice. The wait time may be increased for some bronchodilators
An increase in FEV1 and/or FVC ≥12% of control and ≥200 mL constitutes a positive bronchodilator response
In the absence of a significant increase in FEV1 and/or FVC, an improvement in lung function parameters within the tidal breathing range, such as increased partial flows and decrease of lung hyperinflation, may explain a decrease in dyspnoea
The lack of a bronchodilator response in the laboratory does not preclude a clinical response to bronchodilator therapy
  • FEV1: forced expiratory volume in one second; FVC: forced vital capacity.