Table 2—

Percentage of patients with one or more exacerbation and mean number of exacerbations per patient per year according to thepost hoc classification of exacerbation severity

TiotropiumPlacebop-value
All severities
 Patients with one or more exacerbations %49.960.3<0.01
 Exacerbations per patient per yr1.572.41<0.001
Moderate-to-severe
 Patients with one or more exacerbations %42.553.4<0.001
 Number of exacerbations per patient per yr1.101.69<0.001
Mild
 Patients with one or more exacerbations %13.115.6ns
 Number of exacerbations per patient per yr0.470.72ns
  • ns: nonsignificant.