Table 1—

Clinical characteristics, haemodynamic parameters, lung function tests and bronchoalveolar lavage results in eight patients with pulmonary veno-occlusive disease (PVOD) and 11 patients with idiopathic pulmonary arterial hypertension (IPAH)

PVODIPAHp-value
Clinical characteristics
 Subjects n811
 Age yrs52±1744±10ns
 Sex male/female5/33/8ns
 Smoking n (%)6 (75)4 (36)ns
 Raynaud's phenomenon n (%)1 (12.5)1 (9)ns
 NYHA functional class n (%)
  I–II2 (25)2 (18)ns
  III–IV6 (75)9 (82)ns
 Right-ventricular failure n (%)8 (100)5 (45)<0.05
 Digital clubbing n (%)2 (25)0ns
 Crackles n (%)2 (25)0ns
 Baseline 6-MWD distance m216±138372±820.02
Haemodynamical parameters
 Mean right-atrial pressure mmHg10±510±5ns
 Mean pulmonary artery pressure mmHg59±858±10ns
 Mean PAWP mmHg7±39±3ns
 Cardiac index L·min−1·m−22.1±0.72.5±0.6ns
 Mixed venous oxygen saturation %57±866±10ns
 Total pulmonary resistance IU·m−231±1525±10ns
Lung function tests
Pa,O2 mmHg58±1178±140.007
Pa,CO2 mmHg32±631±4ns
 FEV1 % pred90±1298±21ns
 VC % pred89±1397±17ns
 TLC % pred93±1597±15ns
DL,CO/VA % pred37±962±160.008
Bronchoalveolar lavage
 Volume mL55±1964±36ns
 Cells per mL410250±366500204300±158200ns
 Lymphocytes %9±811±7ns
 Neutrophils %1±11±1ns
 Macrophages %90±788±7ns
 Haemosiderin-laden macrophages %40±373±60.004
 Golde score81±884±100.002
  • Data are presented as mean±sd, unless otherwise stated. NYHA: New York Heart Association; 6-MWD: 6-min walk distance; PAWP: pulmonary arterial wedge pressure; Pa,O2: arterial oxygen tension; Pa,CO2: arterial carbon dioxide tension; FEV1: forced expiratory volume in one second; % pred: percentage predicted; VC: vital capacity; TLC: total lung capacity; DL,CO/VA: carbon monoxide diffusing capacity/alveolar volume; ns: nonsignificant. 1 mmHg = 0.133 kPa.