Table. 3—

Studies on chemokine mRNA turnover

ChemokineAlternative nameReported stimuli[Refs]
Increase mRNA stabilisationInduce acceleration of mRNA decay
CXCL1GRO-αLPS, IL-152, 65, 70, 71
CXCL2GRO-βLPS, IL-152, 65, 70, 71
CXCL3GRO-γLPS, IL-152, 65, 70, 71
CXCL8IL-8LPS, IL-1, TNF-α, IFN-γ, NO, adenovirus, hypoxiaIL-4, IL-10, GCs31, 54, 56, 60, 62, 64, 65, 72–75
CCL2MCP-1APC, hyperoxia, IL-1, LPSHypoxia, GCs31, 61, 65, 68, 76, 77
CCL3MIP-1αLPSIL-1060, 65
CCL4MIP-1βLPSIL-1060, 65
CCL5RANTESRSV63
CCL11EotaxinTNF-α, IL-4, IFN-γGCs55, 78, 79
CCL13MCP-4GCs80
CCL20MIP-3αFMLP66
  • GRO: growth-related oncogene; IL: interleukin; MCP: monocyte chemotactic protein; MIP: macrophage inflammatory protein; RANTES: regulated upon activation, normal T-cell expressed and secreted; LPS: lipopolysaccharide; TNF: tumour necrosis factor; IFN: interferon; NO: nitric oxide; APC: activated protein C; RSV: respiratory syncitial virus; FMLP: formyl-methionyl-leucyl-phenylalanine; GC: glucocorticoid.