Table. 1—

Human chemokines and their receptors

FamilyCurrent nomenclaturePrevious nomenclature(s)Receptor#
CXCCXCL1GRO-α/MGSA-αCXCR2
CXCL2GRO-β/MGSA-βCXCR2
CXCL3GRO-γ/MGSA-γCXCR2
CXCL4PF4Unknown
CXCL5ENA-78CXCR2
CXCL6GCP-2CXCR1, CXCR2
CXCL7NAP-2CXCR2
CXCL8IL-8CXCR1, CXCR2
CXCL9MIGCXCR3, (CCR3)
CXCL10IP-10CXCR3, (CCR3)
CXCL11I-TACCXCR3, (CCR3)
CXCL12SDF-1α/βCXCR4
CXCL13BLC/BCA-1CXCR5
CXCL14BRAK/bolekineUnknown
CXCL15
CXCL16SR-PSOXCXCR6
CCCCL1I-309CCR8
CCL2MCP-1/MCAFCCR2
CCL3MIP-1α/LD78αCCR1,CCR5
CCL4MIP-1βCCR5
CCL5RANTESCCR1, CCR3, CCR5
CCL6
CCL7MCP-3CCR1, CCR2, CCR3, (CCR5)
CCL8MCP-2CCR3
CCL9/10
CCL11EotaxinCCR3, CCR5, (CCR2)
CCL12CCR2
CCL13MCP-4CCR2, CCR3
CCL14HCC-1CCR1
CCL15HCC-2/Lkn-1/MIP-1δCCR1, CCR3
CCL16HCC-4/LECCCR1
CCL17TARCCCR4
CCL18DC-CK1/PARC/AMAC-1Unknown
CCL19MIP-3β/ELC/exodus-3CCR7
CCL20MIP-3α/LARC/exodus-1CCR6
CCL216Ckine/SLC/exodus-2CCR7
CCL22MDC/STCP-1CCR4
CCL23MPIF-1CCR1
CCL24Eotaxin 2/MPIF-2CCR3
CCL25TECKCCR9
CCL26Eotaxin 3CCR3
CL27CTACK/ILCCCR10
CCL28MECCCR3, CCR10
CXCL1Lymphotactin/SCM-1α/ATACXCR1
SCL2SCM-1βXCR1
CX3CCX3CL1FractalkineCX3CR1
  • GRO: growth-regulated oncogene; MGSA: melanoma growth stimulatory activity; PF: platelet factor; ENA: epithelial neutrophil activating; GCP: granulocyte chemotactic protein; NAP: neutrophil-activating peptide; IL: interleukin; MIG: monokine-induced by interferon (IFN)-γ; IP: IFN-γ-inducible protein; I-TAC: IFN-γ-inducible T-cell chemoattractant; SDF: stromal cell-derived factor; BLC: B-lymphocyte chemoattractant; BCA: B-cell-attracting chemokine; BRAK: breast and kidney-expressed chemokine; SR-PSOX: scavenger receptor for phosphatidylserine and oxidised lipoprotein; MCP: monocyte chemoattractant protein; MCAF: monocyte chemotactic and activating factor; MIP: macrophage inflammatory protein; RANTES: regulated on activation, normal T-cell expressed and secreted; HCC: human CC chemokine; Lkn: leukotactin; LEC: liver-expressed chemokine; TARC: thymus and activation-regulated chemokine; DC-CK1: dendritic cell-derived CC chemokine; PARC: pulmonary and activation-regulated chemokine; AMAC: alternative macrophage activation-associated CC chemokine; ELC: Epstein-Barr virus-induced molecule-1 ligand chemokine; LARC: liver and activation-regulated chemokine; SLC: secondary lymphoid tissue chemokine; MDC: monocyte-derived chemokine; STCP: stimulated T-cell chemoattractant protein; MPIF: myeloid progenitor inhibitory factor; TECK: thymus-expressed chemokine; CTACK: cutaneous T-cell-activating chemokine; ILC: IL-11 recepter alpha-locus chemokine; MEC: mucosae-associated epithelial chemokine; SCM: single C motif; ATAC: activation-induced, chemokine-related molecule. #: antagonist effect in parentheses; : human ligand has not yet been identified. Modified from 8.