Effects of occupational/environmental exposures on lung function in severe α1-antitrypsin (AAT) deficiency
| First author year [ref.] | Exposure | Outcome | Outcome in: AAT deficiency/not exposed | Outcome in: AAT deficiency/exposed | Estimated exposure effect in severe AAT deficiency | Effect modification |
| Silverman 1989 26 | Passive smoking | Difference in prevalence rate of subjects with FEV1 ≤65% pred % | 52 | 76 | ns | Not measurable |
| Piitulainen 1997 27 | Occupational | Difference in FEV1 % pred (sd or 95% CI) | 76 (31) | 63 (29) | −7 (−2.4– −12); subjects ≥50 yrs | Not measurable |
| Piitulainen 1998 28 | Passive smoking | Difference in FEV1/FVC ratio % (95% CI) | 101 (98–104) | 96 (93–98) | −3.4 (−6.5– −1.2) | Not measurable |
| Piitulainen 1998 29 | Occupational | Difference in FEV1 % pred (95% CI) | 89 (85–93) | 59 (43–76) | −18 (−30– −6) | Not measurable |
| Mayer 2000 30 | Occupational | Difference in FEV1 % pred | 40 | 31 | p = 0.032 | Not measurable |
FEV1: forced expiratory volume in one second; CI: confidence interval; FVC: forced vital capacity; ns: nonsignificant.