Table. 2—

Effects of treatment on lung function, exercise capacity and dyspnoea in 15 controls and 27 treated chronic obstructive pulmonary disease patients

BaselineFinalChangeANCOVA p-value NIMV versus s-NIMV
Pa,CO2 mmHgNIMV56.5±648.3±4−8.2<0.0001
s-NIMV56.7±656.0±7−0.7
Pa,O2 mmHgNIMV45.3±553.0±67.7<0.001
s-NIMV47.9±550.1±52.2
HCO3 mEq·L−1NIMV34±329±2−5<0.0001
s-NIMV33±433±40
pHNIMV7.39±0.37.39±0.20ns
s-NIMV7.38±0.27.38±0.20
VT mLNIMV526±158693±196167<0.0001
s-NIMV529±145541±15812
fR breaths·min−1NIMV21±517±5−4<0.0001
s-NIMV20±521±51
VE L·min−1NIMV10.7±311.4±30.7ns
s-NIMV10.4±311.1±30.7
FEV1 LNIMV0.75±0.180.83±0.210.08<0.001
s-NIMV0.76±0.190.76±0.190.00
FVC LNIMV2.32±0.72.55±0.80.23<0.001
s-NIMV2.26±0.72.24±0.7−0.02
FEV1/FVC %NIMV34±934±100ns
s-NIMV35±735±70
P0.1 cmH2O·L−1NIMV4.4±1.73.0±1.2−1.4<0.0001
s-NIMV4.2±1.34.3±1.30.1
P0.1/VT/tI cmH2O·L−1·s−1NIMV8.2±2.85.1±1.7−3.1<0.0001
s-NIMV7.9±3.07.8±2.7−0.1
PI,max cmH2ONIMV53±1361±1480.034
s-NIMV58±1262±124
TTmusNIMV0.14±0.070.09±0.07−0.05<0.0001
s-NIMV0.11±0.030.11±0.040
6MWD mNIMV329±103405±9576<0.0001
s-NIMV380±94393±8413
Borg scale pointsNIMV6.6±1.75.1±1.7−1.5<0.0001
s-NIMV6.3±1.86.2±1.4−0.1
  • Data are expressed as mean±sd. ANCOVA: analysis of covariance; NIMV: noninvasive mechanical ventilation; s-NIMV: sham-NIMV; Pa,O2: arterial oxygen tension; Pa,CO2: carbon dioxide arterial tension; HCO3: serum bicarbonate; VT: tidal volume; fR: breathing frequency; VE: minute ventilation; FEV1: forced expiratory volume in one second; FVC: forced vital capacity; P0.1: mouth occlusion pressure; P0.1/VT/tI: effective respiratory impedance; PI,max: maximal inspiratory pressure; TTmus: tension-time index of inspiratory muscles; 6MWD: 6-min walking distance; ns: not significant.