Table. 1—

Baseline demographic and clinical characteristics

Sequence A#Sequence BAll
Clinical variables
 Subjects n292958
 Sex M:F13:1622:7+35:23
 Age yrs§40.7 (16–71)36.2 (19–60)38.5 (16–70)
 Atopicƒ27 (93)27 (93)54 (93)
 Former smokers3 (10)8 (28)11 (19)
 Taking ICS prior to enrolment15 (52)18 (62)33 (57)
 FEV1 % pred75.0±10.777.1±13.276.1±11.9
 FEV1/FVC ratio0.73±0.090.71±0.100.72±0.10
 PD20 methacholine µmol##0.31 (0.22–0.46)0.42 (0.32–0.56)0.37 (0.29–0.46)
 Total QoL score¶¶0.69±0.100.57±0.080.63±0.09
 ACQ score2.09±0.791.81±0.691.95±0.75
 Patient GAAC++51.2±25.651.7±25.451.4±25.3
Electronic diary variables
 Subjects n242549
 Day symptom score§§1.5 (1.0–2.0)2.0 (1.0–2.0)2.0 (1.0–2.0)
 Night symptom score§§1.0 (0.9–2.0)1.0 (1.0–1.5)1.0 (1.0–2.0)
 Symptom-free days %0.0 (0.0–3.3)0.0 (0.0–0.0)0.0 (0.0–0.0)
 Waking-free nights %47 (13–84)57 (29–100)50 (25–88)
 Day salbutamol use puffs·day−13.0 (1.0–4.4)2.0 (1.0–6.0)3.0 (1.0–5.5)
 Night salbutamol use, puffs·day−12.0 (0.0–3.1)2.0 (0.5–2.0)2.0 (0.0–2.0)
Salbutamol-free days %0.0 (0.0–13.3)0.0 (0.0–0.0)0.0 (0.0–13.0)
 Median DACSƒƒ3.0 (3.0–4.0)4.0 (3.0–4.0)3.0 (3.0–4.0)
  • Data are presented as mean±sd, median (interquartile range) or n (%). M: male; F: female; ICS: inhaled corticosteroids; FEV1: forced expiratory volume in one second; % pred: per cent predicted; FVC: forced vital capacity; PD20: provocative concentration of methacholine causing a 20% fall in FEV1; QoL: quality of life; ACQ: asthma control questionnaire; GAAC: global assessment of asthma control; DACS: daily asthma control score. #: sequence A: montelukast then eformoterol; : sequence B: eformoterol then montelukast; +: p = 0.03 versus sequence A, Chi-squared test; §: mean (range); ƒ: atopy defined as >5 aeroallergens (Dermatophagoides pteronyssinus, rye, cat, Aspergillus, Alternaria) ≥4×4 mm and >saline control; ##: geometric mean (95% confidence intervals); ¶¶: data summarised as square root then back-transformed; ++: visual analogue score for asthma control over last week, 0–100, very poorly controlled to very well controlled; §§: day and night symptom scores, each range 0–4 from pre-set text responses; ƒƒ: asthma control score for last 24 h from electronic diary, range 1–5 (very poorly controlled to very well controlled) in text responses.