Genotype and haplotype frequencies for the−308GA and TNFB polymorphism among cases, controls, survivors and nonsurvivors in acute respiratory distress syndrome
| Cases | Controls | p-value | Nonsurvivors | Survivors | p-value | |
| Subjects | 212 | 441 | 98 | 114 | ||
| −308GA polymorphism# | ||||||
| −308GG | 73 (155) | 73 (320) | 65 (64) | 80 (91) | ||
| −308GA | 22 (47) | 24 (106) | 0.6 | 28 (27) | 18 (20) | <0.05 |
| −308AA | 5 (10) | 3 (15) | 7 (7) | 3 (3) | ||
| TNFB polymorphism# | ||||||
| TNFB11 | 8 (18) | 8 (37) | 6 (6) | 11 (12) | ||
| TNFB12 | 48 (101) | 45 (198) | 0.8 | 53 (52) | 43 (49) | 0.3 |
| TNFB22 | 44 (93) | 47 (206) | 41 (40) | 46 (53) | ||
| Haplotypes¶ | ||||||
| −308G:TNFB1 | 33 (70) | 30 (130) | 0.4 | 27 (26) | 39 (44) | 0.08 |
| −308G:TNFB2 | 90 (190) | 90 (396) | >0.9 | 91 (89) | 89 (44) | 0.7 |
| −308A:TNFB1 | 26 (56) | 27 (121) | 0.9 | 35 (34) | 19 (101) | 0.01 |
| −308A:TNFB2 | 2 (5) | 2 (8) | 0.8 | 3 (3) | 2 (2) | 0.7 |
Data presented as % (n), unless otherwise stated. #: for the −308GA and TNFB polymorphisms, independence was tested between the genotypes with Fischer's exact test; ¶: for haplotypes, Fischer's exact p-value was obtained by comparing those individuals with one or more copies of the haplotype to individuals with no copies.