Table. 2—

Association of atopy with different operational definitions of asthma

Operational definition of asthmaNonatopic %Atopic %Adj OR#Lower 95% CIUpper 95% CIz-value
Subjects n74573840
Wheeze
 Wheeze17.928.91.841.67 2.0212.62
 Wheeze, breathlessness8.115.82.121.88 2.4011.87
 Wheeze, breathlessness, no cold4.711.82.612.25 3.0312.61
Bronchial hyperresponsiveness
 Slope>25%19.834.92.312.11 2.5317.74
 >20% at 1 mg8.922.73.202.85 3.5919.74
 Slope>10%6.117.53.463.03 3.9518.38
Wheeze and BHR
 Wheeze, BHR3.412.44.133.50 4.8616.94
 Wheeze, breathlessness, BHR1.98.84.984.05 6.1115.29
 Wheeze, breathlessness, no cold, BHR1.37.15.844.58 7.4514.22
ECRHS Definition+
 Any 1 of 3 variables5.012.42.762.38 3.1913.58
 Any 2 of 3 variables1.0 10.15.754.37 7.5612.49
 All 3 variables0.34.76.924.4210.84 8.47
Score
 Any 1 of 8 questions29.040.41.701.56 1.8512.16
 Any 2 of 8 questions11.621.32.121.90 2.3613.50
 Any 3 of 8 questions5.713.32.572.23 2.9513.20
 Any 4 of 8 questions2.78.83.412.84 4.1113.00
 Any 5 of 8 questions1.56.14.393.46 5.5612.19
 Any 6 of 8 questions0.74.15.774.18 7.9510.69
 Any 7 of 8 questions0.42.36.554.2010.21 8.30
 All 8 questions0.10.97.013.3314.78 5.12
  • Adj: adjusted; OR: odds ratio; CI: confidence interval; BHR: bronchial hyperresponsivness; ECRHS: European Community Respiratory Health Study. #: adjusted for age, sex and centre; : >20% fall in forced expiratory volume in one second at 1 mg; +: woken by shortness of breath, attack of asthma or asthma medication.