Three-weekly morning/evening peak flow and number of puffs per day of salbutamol
| Tiotropium | Formoterol | Tiotropium and formoterol | |
| Peak flow L·min−1 | |||
| Morning | 262±2.6 | 259±2.6 | 268±2.5# |
| Evening | 274±2.8 | 266±2.8 | 283±2.6¶ |
| Salbutamolp.r.n. | |||
| Daytime | 2.41±0.14 | 2.37±0.14 | 1.81±0.13+ |
| Night-time | 0.56±0.05 | 0.52±0.05 | 0.52±0.05 |
Data are presented as mean±se. #: p<0.02 versus formoterol; ¶: p<0.01 versus tiotropium and p<0.0001 versus formoterol; +: p<0.003 versus tiotropium plus formoterol. Means are adjusted for period, centre and patient within centre.