Table. 3—

Baseline characteristics for the clinically evaluable uncomplicated and complicated patients

UncomplicatedComplicated
Levo.Azithro.p-valueLevo.Amox./clav.p-value
Subjects n143151120126
Sex
 Male71 (49.7)65 (43.0)0.29366 (55.0)64 (50.8)0.525
 Female72 (50.3)86 (57.0)54 (45.0)62 (49.2)
Age yrs
 18–247 (4.9)8 (5.3)1 (0.8)1 (0.8)
 25–3413 (9.1)11 (7.3)1 (0.8)1 (0.8)
 35–3913 (9.1)21 (13.9)5 (4.2)4 (3.2)
 40–4527 (18.9)19 (12.6)13 (10.8)10 (7.9)
 46–6451 (35.7)62 (41.1)56 (46.7)68 (54.0)
 ≥6532 (22.4)30 (19.9)44 (36.7)42 (33.3)
 Mean50.7±15.0451.0±15.870.86959.0±13.0959.3±12.230.853
Weight lbs177.7±41.15181.9±48.360.424185.8±56.30173.6±44.470.060
Race
 Caucasian84 (58.7)93 (61.6)0.60193 (77.5)96 (76.2)0.905
 Black44 (30.8)44 (29.1)22 (18.3)28 (22.2)
 Asian2 (1.4)3 (2.0)1 (0.8)1 (0.8)
 Hispanic12 (8.4)9 (6.0)3 (2.5)1 (0.8)
 Other#1 (0.7)2 (1.3)1 (0.8)0 (0.0)
Smoking history
 Nonsmoker28 (19.6)28 (18.5)0.4396 (5.0)7 (5.6)0.469
 Current smoker77 (53.8)93 (61.6)56 (46.7)64 (50.8)
 Ex-smoker38 (26.6)30 (19.9)58 (48.3)55 (43.7)
Pack-yrs n28.7±26.0 (115)27.4±22.8 (121)0.68341.4±31.5 (113)47.8±37.4 (116)0.163
FEV1 % pred
 <50%4 (2.8)1 (0.7)0.49360 (50.0)68 (54.0)0.534
 50–65%31 (21.7)33 (21.9)32 (26.6)32 (25.4)
 66–80%45 (31.5)45 (29.8)14 (11.7)12 (9.5)
 ≥80%63 (44.0)72 (47.6)14 (11.7)14 (11.1)
Corticosteroid usage
 Acute steroids
  Systemic8 (5.6)5 (3.3)0.4035 (4.2)6 (4.8)1.000
  Inhaled1 (0.7)1 (0.7)1.0002 (1.7)2 (1.6)1.000
 Chronic steroids
  Systemic16 (11.2)15 (9.9)0.85020 (16.7)17 (13.5)0.593
  Inhaled17 (11.9)12 (7.9)0.34125 (20.8)22 (17.5)0.521
Exacerbation frequency past 12 months
 04 (2.8)8 (5.3)0.1897 (5.8)5 (4.0)0.150
 1–3138 (96.5)143 (94.7)44 (36.7)35 (27.8)
 4–61 (0.7)0 (0.0)60 (50.0)78 (61.9)
 ≥70 (0.0)0 (0.0)9 (7.5)8 (6.3)
Continuous sputum
 Yes89 (62.2)94 (62.3)1.00088 (73.7)83 (65.9)0.215
 No54 (37.8)57 (37.7)32 (26.7)43 (34.1)
  • Data are presented as n (%) or mean±sd, unless otherwise stated. Levo.: levofloxacin; azithro.: azithromycin; amox.: amoxicillin; clav.: clavulanate; FEV1: forced expiratory volume in one second; % pred: % predicted. #: other includes Puerto Rican, Latino and Native American.