Table. 1—

Aetiology of bronchiectasis

AetiologySubjects nFEV1FVC
Immunodeficiency4675 (15–133)76 (14–122)
 Primary immune defects
  Panhypogammaglobulinaemia3
  Hyper-IgE syndrome2
  Mannose-binding protein deficiency1
  Qualitative antibody deficiency1
  IgG deficiency4
  Combined variable immunodeficiency14
  Undefined combined immunodeficiency6
  X-linked agammaglobulinaemia4
  MHC class-2 deficiency1
  B-cell deficiency1
  Chronic mucocutaneous candidiasis1
  Chronic granulomatous disease1
  Wiskott–Aldrich syndrome1
 Secondary immune defects
  Post-chemotherapy1
  AIDS5
Idiopathic3569 (34–104)78 (51–116)
Aspiration2571 (33–91)69 (36–105)
Primary ciliary dyskinesia2066 (39–100)82 (46–111)
Childhood respiratory infection539 (26–62)64 (42–76)
 Measles2
 Pertussis1
 Adenovirus1
 Tuberculosis1
Congenital structural malformation583 (78–85)92 (84–98)
 Congenital lobar emphysema1
 Pulmonary artery sling1
 Bronchial atresia with bronchocoele1
 Yellow nail syndrome1
 Bronchomalacia1
  • Data are presented as median percentage predicted (range), unless otherwise stated. FEV1: forced expiratory volume in one second; FVC: forced vital capacity; Ig: immunoglobulin; MHC: major histocompatibility complex.