Table. 4—

Matched crude and adjusted rate ratios (RR) for acute myocardial infarction in relation to the duration of inhaled corticosteroid use

CaseControls#Crude RRAdjusted RR
Subjects n3711864
No exposure in the last 12 months214 (57.7)1000 (54.3)1 (ref. group)1 (ref. group)
Currently exposed
 1–30 days25 (6.7)130 (6.8)0.92 (0.58–1.45)0.78 (0.47–1.30)
 31–60 days19 (5.1)58 (3.1)1.53 (0.88–2.65)1.17 (0.64–2.16)
 >61 days27 (7.3)171 (8.8)0.77 (0.49–1.19)0.70 (0.43–1.15)
Duration months3.1±5.14.7±3.30.97 (0.93–1.01)+
  • Data are presented as n (%), mean±sd or RR (95% confidence interval), unless otherwise stated. ref.: reference. #: to account for the variable number of controls in each matched set, all means, sd and percentages were weighted by the inverse of the number of controls in each set; : adjusted for age and duration of chronic obstructive pulmonary disease (COPD; by study design), and for sex, number of COPD exacerbations, number of prescriptions of bronchodilators in the last 12 months (none, 1–12, >12), oral corticosteroid dose dispensed in the last 12 months, hospitalisation in the last 3 months, diabetes, systemic hypertension, ischaemic heart disease, and heart failure; +: associated with an increase of 1 month of continuous exposure.