Table. 3—

Matched crude and adjusted rate ratios (RR) for acute myocardial infarction in relation to the quantity of inhaled corticosteroids dispensed in the prior year

CaseControls#Crude RRAdjusted RR
Subjects n3711864
No exposure in the last 12 months214 (57.7)1000 (54.3)1 (ref. group)1 (ref. group)
Average daily dose in the last 12 months beclomethasone-equivalent units
 ≤50 µg·day−119 (5.1)123 (6.3)0.74 (0.44–1.24)0.82 (0.48–1.42)
 50–200 µg·day−147 (12.7)322 (17.6)0.68 (0.48–0.97)0.68 (0.47–0.99)
 200–500 µg·day−139 (10.5)199 (10.6)0.92 (0.63–1.34)0.84 (0.55–1.29)
 >500 µg·day−152 (14.0)220 (11.3)1.15 (0.81–1.63)1.07 (0.71–1.60)
  • Data are presented as n (%) or RR (95% confidence interval), unless otherwise stated. ref.: reference. #: to account for the variable number of controls in each matched set, all means, sd and percentages were weighted by the inverse of the number of controls in each set; : adjusted for age and duration of chronic obstructive pulmonary disease (COPD; by study design), and for sex, number of COPD exacerbations, number of prescriptions of bronchodilators in the last 12 months (none, 1–12, >12), oral corticosteroid dose dispensed in the last 12 months, hospitalisation in the last 3 months, diabetes, systemic hypertension, ischaemic heart disease and heart failure.