The Child–Pugh class, a measure of severity of liver disease, is based on points assigned for the degree of ascites (1: absent; 2: slight; and 3: severe), serum concentrations of bilirubin (SBR; 1: <34 μmol·L⁻¹; 2: 34–51 μmol·L⁻¹; and 3: >51 μmol·L⁻¹) and albumin (sAl; 1: >35 g·L⁻¹; 2: 28–35 g·L⁻¹; and 3: <28 g·L⁻¹), the international normalised ratio (INR; 1: <1.7; 2: 1.8–2.3; and 3: >2.3) and the degree of encephalopathy (1: none; 2: grade 1–2; and 3: grade 3–4). A total score of 5–6 is considered Child class A, 7–9 class B and 10–15 class C. The normal range for alanine aminotransferase (ALT) and aspartate aminotransferase (AST) is 0.10–0.52 μmol·L⁻¹·s⁻¹. SCr: serum creatinine; OAC: oral anticoagulation (INR assumed to be 1 for calculation of Child–Pugh score); BL: baseline; Mod: moderate.