Table 3—

Aldehydes in exhaled breath condensate (EBC) and induced sputum (IS) from asthmatics, subjects with chronic obstructive pulmonary disease (COPD) and healthy nonsmoking controls

LODAsthmaCOPDControl
EBCISEBCISEBCIS
MDA1.021.1 (9–53.7)134.3 (97.1–262.8)*24 (11.8–32.6)128.2 (92.5–158.1)#,¶9.8 (9.2–10.6)87.4 (64.5–108.5)+
Acrolein1.048.3 (18.1–127.1)116.8 (0.5–197.7)*55.6 (14.4–94.1)147.0 (55.6–264.6)#,¶9.4 (6.9–20.3)+ND
C61.040.2 (17.2–63.7)58.4 (24.8–102.9)*32 (20.8–61.2)49 (32–132.5)#,¶22.2 (15.3–38.1)29 (20.5–50.5)+
C71.018.7 (8.7–43.6)42 (20.1–143.6)*17.7 (7.5–42.1)60.6 (32.2–111.6)#15.2 (7.7–33.8)51.7 (29.7–80.38)+
C91.031.1 (22.8–70.1)51.6 (35.1–145.9)*26.7 (16.5–34.4)84.2 (31.9–256.6)#,¶27.2 (14.9–47.5)39.7 (18–102.9)+
4-HHE0.3ND (ND–7.1)2.98 (ND–70)ND (ND–35.9)3.1 (ND–21.4)0.7 (ND–3.3)ND (ND–5.4)
4-HNE0.60.9 (ND–2.3)0.5 (ND–3.8)0.9 (ND–2.9)1.1 (ND–10)1.3 (0.6-6.1)0.9 (ND–4.9)
  • LOD: limit of detection; MDA: malondialdehyde; C6: n-hexanal; C7: n-heptanal; C9: n-nonanal; 4-HHE: 4-hydroxynonenal; 4-HNE: 4-hydroxyhexenal; ND: not detectable. *: p<0.05 EBC versus IS in asthma; #: p<0.05 EBC versus sputum in COPD; : p<0.05 versus control values; +: EBC versus sputum in controls.