Table 2—

Individual functional classes (New York Heart Association (NYHA)) and 6-min walk distance (6-MWD)

Patient no.	Baseline 1 before bosentan		3 months after introduction of bosentan		Baseline 2 before sildenafil		3 months after addition of sildenafil		6–12 months after addition of sildenafil
Patient no.	NYHA	6-MWD	NYHA	6-MWD	NYHA	6-MWD	NYHA	6-MWD	NYHA	6-MWD
1	III	393	II	478	III	297	III	363	III	373
2^#	III	336	III	428	III	226	III	354	II	410
3	III	367	III	406	III	354	II	450	II	462
4	III	337	III	403	IV	132	II	414	II	382
5	III	420	II	497	III	371	III	421	II	481
6	III	328	III	406	III	353	III	425	III	425
7^¶	III	330	III	343	III	303	III	335	III	345
8	IV	198	III	232	III	252	III	290	III	328
9	III	406	III	434	IV	203	II	480	II	450

^#: receiving inhaled iloprost since 15 months before bosentan was started and iloprost was continued throughout the observation period; ^¶: bosentan replaced continuous intravenous iloprost that had been given for 2 yrs but had to be withdrawn after several episodes of life-threatening line sepsis, sildenafil was added 11 months after introduction of bosentan