Table 1—

Subjects' characteristics

ControlEmphysema
Patient n1010
Age yrs63.5 (54–67)65.5 (58–70)
Sex
 Male610
 Female40
Height cm175.5 (159.0–177.0)175.5 (168.0–182.0)
Weight Kg75.5 (62.0–80.0)65.5 (65.0–82.0)
VC % pred102.4 (87.6–110.5)74.6 (72.0–90.0)*
FEV1 % pred94.8 (83.9–103.3)39.6 (34.2–46.0)**
FEV1/VC % pred95.8 (94.2–102.0)49.4 (44.1–54.0)**
FEV1/FVC %78.7 (76.3–79.4)39.3 (34.0–44.7)
ITGV % pred103.8 (94.4–110.0)175.5 (165.8–193.9)**
RV L2.3 (2.0–2.5)4.6 (4.3–6.3)**
TLC L6.6 (4.8–7.1)8.4 (7.5–9.9)**
RV/TLC %41.6 (32.6–45.2)59.1 (52.3–65.0)**
GOLD n
 000
 I00
 IIa02
 IIb08
 III00
Smoking history# pack-yrs22.5 (20–30)47.5 (40–75)*
DT h25.0 (21.7–25.4)31.2 (29.3–40.9)**
DT cryopreserved+ h29.0 (26.0–36.8)36.3 (34.1–47.9)*
  • Data presented as mean (interquartile range) unless otherwise stated

  • VC: vital capacity

  • FEV1: forced expiratory volume in one second

  • ITGV: intrathoracic gas volume

  • RV: residual volume

  • TLC: total lung capacity

  • GOLD: Global Initiative for Chronic Obstructive Lung Disease

  • DT: doubling time

  • #: estimated pack-yrs from patient files

  • +: n=8 proliferation experiments in emphysema and n=9 in controls due to insufficient cell numbers. *: p<0.05

  • **: p<0.01 regarding the difference between groups