Cefepime concentrations in plasma (Čp,cefepime)¶, bronchoalveolar lavage fluid (CBAL,cefepime)+ and epithelial lining fluid (CELF,cefepime)
| Control | ALI | |
| Čp,cefepime mg·L−1 | 24.4±1.7 | 35.2±2.7* |
| CBAL,cefepime mg·L−1 | 0.51±0.08 | 15.09±1.83* |
| CELF,cefepime | ||
| Method A mg·L−1 | 22.6±4.2 | 34.6±5.3 |
| % Čp,cefepime | 95.4±19.3 | 100.3±14.5 |
| Method B mg·L−1 | 4.1±0.8# | 25.5±3.2*,# |
| % Čp,cefepime | 16.4±2.7 | 73.9±8.4 |
| Method B, single cycle mg·L−1 | 14.9±4.2 | 25.8±3.2*,# |
| % Čp,cefepime | 59.0±15.4 | 75.8±9.5 |
| Method C mg·L−1 | 15.6±3.2 | 24.8±3.3*,# |
| % Čp,cefepime | 62.0±12.5 | 74.0±10.4 |
Data are presented as mean±sem (n=9)
CELF,cefepime methods: A: technetium-99m diethylenetriaminepenta-acetic acid method
B: urea method using the fluid pooled from the six lavage cycles
B, single cycle: urea method using the fluid from the first lavage cycle alone
and C: urea method with correction for urea diffusion during lavage (see Appendix)
¶: steady state
+: mean from all six lavages
*: p<0.05 versus control
#: p<0.05 versus CELF,cefepime method A