Table 3—

Distribution of combinations of microsomal epoxide hydrolase (mEPHX) and glutathione S-transferase (GST) M1 and P1 genes among COPD patients and controls

Genetic factors#nCOPDControlsOR (95% CI)
Subjects n184212
0+52 (28.3)93 (43.9)1
1137 (74.5)125 (59.0)2.3 (1.1–4.3)***
289 (48.4)47 (22.2)3.6 (1.9–8.6)***
367 (36.4)18 (8.5)6.8 (1.6–17.7)***
  • Data are presented as n (%) unless otherwise indicated

  • OR: odds ratio

  • CI: confidence interval

  • #: ≥1 mEPHX exon 3 slow allele, GSTM1-null genotype and Ile105/Ile105 GSTP1 added in sequence

  • : adjusted for age, sex and cumulative cigarette consumption

  • +: reference type: no mEPHX exon 3 slow alleles, non-null GST M1 and T1 genotype and Val105/Val105 GSTP1

  • ***: p<0.001