Table 2—

Distribution of COPD associated with selected genetic polymorphisms of xenobiotic-metabolising enzymes

PolymorphismCOPDControlsOR# (95% CI)
Subjects n184212
mEPHX exon 3
 Tyr113/Tyr11333 (17.9)56 (26.4)1
 Tyr113/His11384 (45.7)92 (43.4)1.6 (0.8–3.1)
 His113/His11367 (36.4)64 (30.2)1.9 (0.9–3.8)
 His113 allele frequency0.590.48
mEPHX exon 4
 His139/His139138 (75.0)139 (65.6)1
 His139/Arg13943 (23.4)66 (31.1)0.6 (0.3–1.1)
 Arg139/Arg1393 (1.6)7 (3.3)0.4 (0.1–2.6)
 Arg139 allele frequency0.130.19
GSTM1
 Non-null genotype71 (38.6)122 (57.5)1
 Null genotype113 (61.4)90 (42.5)2.2 (1.3–3.5)
GSTT1
 Non-null genotype85 (46.2)100 (47.2)1
 Null genotype99 (53.8)112 (52.8)0.9 (0.6–1.6)
GSTP1
 Ile105/Ile10597 (52.7)99 (46.7)1.6 (0.7–6.3)
 Ile105/Val10578 (42.4)98 (46.2)1.2 (0.4–3.9)
 Val105/Val1059 (4.9)15 (7.1)1
 Ile105 allele frequency0.740.64
  • Data are presented as n (%) unless otherwise indicated

  • OR: odds ratio

  • CI: confidence interval

  • mEPHX: microsomal epoxide hydrolase

  • Tyr: tyrosine

  • His: histidine

  • Arg: arginine

  • GST: glutathione S-transferase

  • Ile: isoleucine

  • Val

  • valine

  • #: adjusted for age, sex and cumulative cigarette consumption

  • : p=0.004