Table 5

Measurements at a standardised time during constant-load exercise after treatment with placebo and salmeterol

Dyspnoea Borg3.6±0.42.7±0.3#
Leg discomfort Borg4.0±0.33.7±0.4
V'O2 mL·kg−1·min−114.1±0.914.7±1.1
V'CO2 L·min−11.01±0.101.09±0.12*
V'E L·min−131.9±2.434.0±2.7*
fR breaths·min−129.0±1.227.7±1.2
VT L1.12±0.091.23±0.08*
IC L1.48±0.111.65±0.09*
Change in IC from rest L−0.34±0.04−0.50±0.05*
IRV L0.36±0.050.43±0.03
EILV %TLC95±194±1
  % pred TLC118±4117±4
VT/tE L·s−10.87±0.070.93±0.08*
VT/tI L·s−11.42±0.091.50±0.10*
tE s1.36±0.071.42±0.07
fc beats·min−1109±3111±4
Sa,O2 %93.7±0.594.1±0.3
  • Data are presented as mean±sem

  • V'O2: oxygen uptake

  • V'CO2: carbon dioxide output

  • V'E: ventilation

  • fR: respiratory frequency

  • VT: tidal volume

  • IC: inspiratory capacity

  • IRV: inspiratory reserve volume

  • EILV: end-inspiratory lung volume

  • TLC: total lung capacity

  • tE: expiratory time

  • VT/tE: mean expiratory tidal flow rate

  • tI: inspiratory time

  • VT/tI: mean inspiratory tidal flow rate

  • ttot: duration of total breathing cycle

  • tI/ttot: inspiratory duty cycle

  • fc: cardiac frequency

  • Sa,O2: arterial oxygen saturation

  • % pred: per cent predicted

  • : 3.4±0.5 min

  • *: p<0.05

  • #: p=0.07 versus placebo