End-exercise# measurements in the incremental protocol and post-dose constant-load protocols at 75% of the peak work-rate achieved in incremental testing¶
| Incremental | Constant-load | ||
| Placebo | Salmeterol | ||
| Exercise time min | NA | 4.5±0.7 | 6.0±0.8* |
| Work-rate W | 60±7 | 46±5 | 46±5 |
| Dyspnoea Borg | 5.1±0.3 | 4.7±0.4 | 4.2±0.3 |
| Leg discomfort Borg | 5.3±0.3 | 5.2±0.4 | 5.4±0.5 |
| Reason for stopping n | |||
| Breathing discomfort | 9 | 11 | 3 |
| Leg discomfort | 6 | 6 | 11 |
| Breathing and legs | 8 | 6 | 6 |
| Other | 0 | 0 | 3 |
| V'O2 mL·kg−1·min−1 | 14.8±1.1 | 14.6±1.0 | 15.6±1.0* |
| V'CO2 L·min−1 | 1.12±0.12 | 1.06±0.11 | 1.18±0.10* |
| V'E L·min−1 | 34.1±2.7 | 33.3±2.5 | 36.8±2.5* |
| fR breaths·min−1 | 30.7 ± 1.4 | 30.6 ± 1.1 | 29.6 ± 1.1 |
| VT L | 1.13±0.09 | 1.10±0.08 | 1.25±0.08* |
| IC L | 1.47±0.09 | 1.44±0.11 | 1.66±0.10* |
| IRV L | 0.34±0.04 | 0.33±0.06 | 0.41±0.05 |
| EILV % pred TLC | 116±3 | 118±4 | 117±4 |
| VT/tE L·s−1 | 0.92±0.08 | 0.89±0.08 | 0.99±0.08* |
| VT/tI L·s−1 | 1.50±0.11 | 1.47±0.10 | 1.61±0.09* |
| tI/ttot | 0.38±0.01 | 0.38±0.01 | 0.38±0.01 |
| fc beats·min−1 | 114±3 | 113±3 | 116±4 |
| Sa,O2 % | 93.3±0.6 | 93.1±0.7 | 93.9±0.5 |
Data are presented as mean±sem
V'O2: oxygen uptake
V'CO2: carbon dioxide output
V'E: ventilation
fR: respiratory frequency
VT: tidal volume
IC: inspiratory capacity
IRV: inspiratory reserve volume
EILV: end-inspiratory lung volume
TLC: total lung capacity
tE: expiratory time
VT/tE: mean expiratory tidal flow rate
tI: inspiratory time
VT/tI: mean inspiratory tidal flow rate
ttot: duration of total breathing cycle
tI/ttot: inspiratory duty cycle
fc: cardiac frequency
Sa,O2: arterial oxygen saturation
NA: not applicable
% pred: per cent predicted
#: mean over last 30 s of loaded exercise
¶: 33±3% pred maximum
*: p<0.05 versus placebo