Table 2

End-exercise# measurements in the incremental protocol and post-dose constant-load protocols at 75% of the peak work-rate achieved in incremental testing

Exercise time minNA4.5±0.76.0±0.8*
Work-rate W60±746±546±5
Dyspnoea Borg5.1±0.34.7±0.44.2±0.3
Leg discomfort Borg5.3±0.35.2±0.45.4±0.5
Reason for stopping n
 Breathing discomfort9113
 Leg discomfort6611
 Breathing and legs866
V'O2 mL·kg−1·min−114.8±1.114.6±1.015.6±1.0*
V'CO2 L·min−11.12±0.121.06±0.111.18±0.10*
V'E L·min−134.1±2.733.3±2.536.8±2.5*
fR breaths·min−130.7 ± 1.430.6 ± 1.129.6 ± 1.1
VT L1.13±0.091.10±0.081.25±0.08*
IC L1.47±0.091.44±0.111.66±0.10*
IRV L0.34±0.040.33±0.060.41±0.05
EILV % pred TLC116±3118±4117±4
VT/tE L·s−10.92±0.080.89±0.080.99±0.08*
VT/tI L·s−11.50±0.111.47±0.101.61±0.09*
fc beats·min−1114±3113±3116±4
Sa,O2 %93.3±0.693.1±0.793.9±0.5
  • Data are presented as mean±sem

  • V'O2: oxygen uptake

  • V'CO2: carbon dioxide output

  • V'E: ventilation

  • fR: respiratory frequency

  • VT: tidal volume

  • IC: inspiratory capacity

  • IRV: inspiratory reserve volume

  • EILV: end-inspiratory lung volume

  • TLC: total lung capacity

  • tE: expiratory time

  • VT/tE: mean expiratory tidal flow rate

  • tI: inspiratory time

  • VT/tI: mean inspiratory tidal flow rate

  • ttot: duration of total breathing cycle

  • tI/ttot: inspiratory duty cycle

  • fc: cardiac frequency

  • Sa,O2: arterial oxygen saturation

  • NA: not applicable

  • % pred: per cent predicted

  • #: mean over last 30 s of loaded exercise

  • : 33±3% pred maximum

  • *: p<0.05 versus placebo