Table 2—

Comparisons of potential risk factors and the outcomes of severe acute respiratory syndrome (SARS) patients with and without spontaneous pneumomediastinum (SP)

ParameterNo SPSPp-value
Subjects n9913
Mean±sd age yrs39.4±12.934.1±9.60.153
Male38 (38.4)8 (61.55)0.138
Smoking status: nonsmoker, exsmoker, current smoker92, 4, 313, 0, 00.612
(93, 4, 3)(100, 0, 0)
Active comorbidity13 (13.1)3 (23.1)0.394
Apparently normal chest radiograph on admission23 (23.2)5 (38.5)0.305
Multilobar involvement on initial chest radiograph20 (20.2)1 (7.7)0.456
Haemoglobin g·dL−113.5±1.614.2±0.80.052
Initial total peripheral WBC count ×109·L−16.3±2.17.5±2.70.055
Initial lymphocyte count ×109·L−10.9±0.50.8±0.30.458
Initial platelet count ×109·L−1170±49172±370.910
Initial urea mmol·L−14.1±1.24.4±1.10.475
Initial creatinine µmol·L−185.5±16.090.7±14.30.266
Initial LDH IU·L−1379 (313–449)344 (296–518)0.663
peak LDH IU·L−1583 (471–746)863 (702–1485)0.001
Cumulative methylprednisolone dose g2.3±1.12.4±0.50.741
Viral load in NP specimen on presentation log10 RNA copies·mL−10 (0–5.0)0 (0–4.6)0.493
Viral load in NP specimen peak log10 RNA copies·mL−10 (0–5.3)4.5 (0–6.6)0.169
Intubation10 (10.1)5 (38.5)0.015
Death10 (10.1)4 (30.8)0.057
  • Data are presented as mean±sd, n (%) or median (interquartile range) unless otherwise stated

  • WBC: white blood cell

  • NP: nasopharyngeal

  • LDH: lactate dehydrogenase