Table 1—

Baseline characteristics at randomisation

Constant-dose groupStep-down group
Subjects n2827
Females n1313
Age at study entry yrs7.8 (0.2)8.1 (0.3)
Duration of asthma yrs5.0 (0.4)5.0 (0.4)
Standing height cm129.2 (1.7)132.5 (1.7)
PD20 methacholine µg30 (22–43)36 (26–53)
IgE IU·L−1418 (252–695)560 (386–814)
FEV1 L1.41 (0.06)1.53 (0.07)
  • Data are presented as n, mean (se) and geometric mean (range)

  • PD20: provocative dose of methacholine causing a 20% drop in forced expiratory volume in one second

  • IgE: immunoglobulin E

  • FEV1: forced expiratory volume in one second