Spearman's correlations (ρ) of changes (Δ) in clinical and inflammatory parameters with Δ in provocative concentration causing a 20% fall in forced expiratory volume in one second (PC20) of methacholine (Mch) or PC20 of adenosine-5'-monophosphate (AMP) during a 1-yr smoking cessation
ΔPC20 Mch | ΔPC20 AMP | |||
ρ | p-value | ρ | p-value | |
ΔFEV1 % pred | 0.075 | 0.80 | 0.18 | 0.53 |
ΔFEV1/VC % | −0.106 | 0.72 | 0.06 | 0.85 |
ΔsGaw 1·kPa−1·s−1 | 0.004 | 0.99 | 0.077 | 0.79 |
Sputum 103·mL−1 | ||||
Δ Cell concentration | −0.32 | 0.27 | 0.044 | 0.8 |
Δ Eosinophils | −0.036 | 0.91 | −0.36 | 0.23 |
Δ Neutrophils | 0.18 | 0.56 | −0.008 | 0.98 |
Δ Macrophages | −0.15 | 0.64 | 0.083 | 0.79 |
Δ Lymphocytes | 0.34 | 0.26 | 0.28 | 0.36 |
Δ Epithelial cells | −0.11 | 0.71 | −0.14 | 0.65 |
FEV1: forced expiratory volume in one second
VC: vital capacity
sGaw: airway conductance