Table 3

Treatment differences in lung function parameters for the tiotropium group as compared to the placebo group

	Trough Response		Peak Response
	Day 21	Day 42	Day 0	Day 21	Day 42
FEV₁ L	0.10±0.03***	0.12±0.03***	0.17±0.02^#	0.22±0.03^#	0.22±0.04^#
FVC L	0.19±0.06***	0.25±0.06^#	0.37±0.04^#	0.41±0.06^#	0.43±0.06^#
FEV₁/FVC %	0.8±0.6	0.3±0.6	0.5±0.6	1.5±0.7*	1.4±0.8
SG_aw 1·cmH₂O⁻¹·sec⁻¹	0.015±0.006*	0.006±0.002**	0.016±0.002^#	0.029±0.007^#	0.022±0.003^#
IC L	0.10±0.05*	0.10±0.05*	0.20±0.04^#	0.25±0.06***	0.24±0.06***
RV L	−0.23±0.10*	−0.36±0.09***	−0.50±0.08^#	−0.51±0.10^#	−0.56±0.10^#
FRC L	−0.17±0.08*	−0.30±0.08***	−0.41±0.07^#	−0.41±0.08^#	−0.45±0.08^#
RV/TLC %	−2.2±0.8**	−3.0±0.8***	−4.9±0.6^#	−5.8±0.9^#	−6.0±0.9^#
FRC/TLC %	−1.6±0.6**	−2.1±0.6***	−3.5±0.5^#	−3.9±0.7^#	−4.0±0.7^#
TLC L	−0.07±0.08	−0.20±0.08*	−0.21±0.08**	−0.15±0.09	−0.19±0.09*

Data are presented as tiotropium–placebo, means adjusted for centre and baseline±se
FEV₁: forced expiratory volume in one second
FVC: forced vital capacity
SG_aw: specific airway conductance
IC: inspiratory capacity
RV: residual volume
FRC: functional residual capacity
TLC: total lung capacity
*: p<0.05
**: p<0.01
***: p<0.001
^#: p<0.0001