Table 3—

Current age and clinical variables in a group of European cystic fibrosis (CF) patients, carrying the G85E mutation and a known second mutation not associated with pancreatic sufficiency (PS), compared to two groups of CF patients not carrying the G85E mutation and having either pancreatic insufficiency (PI) or PS

	G85E	PS	PI	G85E versus PS
Subjects n	55	44	55
Current age yrs	18.2±9 (2–51)	18.2±9 (2–52)	18.9±9 (3–46)	0.06^#
Age at time of diagnosis months	22 (3–124)	44 (6–169)	6 (2–28)	0.13^¶
Sweat chloride mEq·L⁻¹	106 (95–115)	100 (78–109)	102 (94–110)	0.0018^¶
Presenting symptoms
Steatorrhea	40	5	84	0.0001⁺
Failure to thrive	40	14	71	0.0001⁺
Meconium ileus	2	0	12	0.49⁺
Respiratory	78	74	63	0.17⁺
Pancreatic insufficiency	54	0	100	<0.0001⁺
Most recent weight for height percentile	57±4	72±5	58±5	0.02^#
Most recent FEV₁ % pred	69±5	85±7	66±5	0.08^#
Chronic P. aeruginosa colonisation	42	23	46	0.0083⁺
Complications
Liver cirrhosis	9	0	11	<0.05⁺
CF‐RD	11	2	13	0.1⁺
DIOS	15	7	9	0.11⁺
Pancreatitis n	2	2	0	0.55⁺

Data are presented as mean±sd (range), median (interquartile range), mean±sem or % unless otherwise stated
Subjects were matched for centre, sex and age
FEV₁: forced expiratory volume in one second; pred: predicted
P. aeruginosa: Pseudomonas aeruginosa
CF‐RD: cystic fibrosis-related diabetes
DIOS: distal intestinal obstruction syndrome
Statistical analysis by paired t‐test^#, Wilcoxon signed-ranks test^¶ and Fisher exact test⁺