Table 3

Relationships between atopy and markers of early infection

	0 infections (or negative for serology section)		≥1 infection (or positive for serology section)		Adjusted OR* (95% CI) (per episode for infections)	p‐value	Adjusted OR^# (95% CI) for association between atopy and number of brothers	p‐value
	n	n (%) atopic	n	n (%) atopic	Adjusted OR* (95% CI) (per episode for infections)	p‐value		p‐value
Serology
Hepatitis A serology	818	303 (37)	78	28 (36)	0.96 (0.56–1.64)	0.88	0.81 (0.69–0.94)	0.01
Helicobacter serology	745	278 (37)	151	53 (35)	0.87 (0.57–1.33)	0.52	0.81 (0.70–0.95)	0.01
Infections
All infections	51	20 (39)	687	249 (36)	1.01 (0.98–1.04)	0.41	0.74 (0.61–0.90)	0.001
All respiratory infections	167	61 (37)	571	208 (36)	1.03 (0.99–1.07)	0.13	0.74 (0.62–0.90)	0.001
All nonrespiratory infections	138	52 (38)	600	217 (36)	0.99 (0.94–1.05)	0.72	0.73 (0.61–0.89)	0.001
Lower respiratory infections	325	117 (36)	413	152 (37)	1.08 (1.01–1.16)	0.02	0.74 (0.61–0.89)	0.001
Upper respiratory infections	263	92 (35)	475	177 (37)	1.00 (0.94–1.07)	0.93	0.74 (0.61–0.89)	0.001
Ear infections	497	182 (37)	241	87 (36)	1.00 (0.86–1.17)	1.00	0.74 (0.61–0.89)	0.001
Skin infections	404	148 (37)	334	121 (36)	1.05 (0.94–1.17)	0.37	0.74 (0.62–0.90)	0.002
Eye infections	541	192 (36)	197	77 (39)	1.21 (0.96–1.51)	0.10	0.74 (0.62–0.90)	0.001
Urinary tract infections	669	247 (37)	69	22 (32)	0.95 (0.68–1.33)	0.76	0.74 (0.61–0.89)	0.001
Gastrointestinal infections	535	210 (39)	203	59 (29)	0.75 (0.59–0.97)	0.02	0.72 (0.60–0.87)	0.001
Other infections	480	184 (38)	258	85 (33)	0.83 (0.68–1.01)	0.05	0.73 (0.61–0.89)	0.001

OR: odds ratio
CI: confidence interval
*: adjusted for age, sex, social class, parental allergic disease and number of brothers
^#: adjusted for age, sex, social class, parental allergic disease and relevant infection count