Table 3

Analysis of exacerbations and oral corticosteroid courses due to exacerbations

B/FBFPlacebo
Time to first exacerbation
 Median number of days25417815496
#RR (95% CI) B/F versus other groups+0.773 (0.611–0.980)*0.705 (0.558–0.891)**0.715 (0.562–0.910)
 p‐value0.0060.5120.901
Total number of exacerbations
 Mean rate per patient per year1.381.601.851.80
 RR (95% CI) B/F versus other groups+0.864 (0.679–1.100)0.745 (0.587–0.945)*0.764 (0.600–0.973)
 p‐value0.0290.3080.828
Exacerbations requiring oral corticosteroids
 Mean rate per patient per year0.630.870.911.14
 RR (95% CI) B/F versus other groups+0.718 (0.543–0.949)*0.695 (0.523–0.923)*0.553 (0.420–0.728)
 p‐value<0.0010.0440.085
  • B: budesonide

  • F: formoterol

  • RR: rate ratio

  • CI: confidence interval

  • #: a RR of 0.715 represents a reduction in rate of 28.5%

  • : versus placebo

  • +: rates from Poisson regression model

  • RR is hazard ratio from Cox proportional hazards model

  • *: p<0.05 in favour of budesonide/formoterol

  • **: p<0.01 in favour of budesonide/formoterol