Histopathological scores relating tissue damage to pneumococcal lung infection in BALB/c and C57BL/6 mice
| Time | Histopathological changes in BALB/c | Histopathological changes in C57BL/6 | ||||||||||
| h | Inflamed tissue % | Cellular influx | Haemorrhage | Oedema | Tissue injury | Total score | Inflamed tissue % | Cellular influx | Haemorrhage | Oedema | Tissue injury | Total score |
| 0 | 0±0 | 0±0 | 0±0 | 0±0 | 0±0 | 0±0 | 0±0 | 0±0 | 0±0 | 0±0 | 0±0 | 0±0 |
| 4 | 6.3±1.3# | 1±0 | 0.8±0.3 | 1±0# | 1±0+ | 23.8±5.5#,+ | 5±0# | 0.5±0.3# | 0±0 | 1±0# | 0±0# | 7.5±1.4# |
| 12 | 27.5±1.4#,+ | 2±0 | 0±0 | 2±0 | 1.5±0.3# | 151.3±11.3#,+ | 17.5±1.4# | 1.3±0.3# | 0±0 | 1.5±0.3# | 1±0 | 66.3±11.8# |
| 48 | 40±2#,¶ | 2±0 | 0±0 | 2±0 | 2±0 | 240±12.2#,¶ | 32.5±1.4# | 2±0 | 0±0 | 1.8±0.3 | 1.5±0.3 | 171.3±14.2# |
| 72 | 31.3±3.1 | 2±0 | 0±0 | 1.8±0.3 | 2±0 | 181.3±23.5 | 27.5±1.4 | 2±0 | 0±0 | 2±0 | 2±0 | 165±8.7 |
Data are presented as mean±sem unless otherwise stated
#: p<0.025 from the previous time point
¶: p<0.05 between BALB/c and C57BL/6 mice
+: p<0.025 between BALB/c and C57BL/6 mice