Biomarkers of inflammation
| Controlled asthma | Severe asthma | Controlled versus severe asthma | |
| Peripheral WBC | |||
| Subjects n | 130 | 162 | ns |
| Total count ×109·L−1 | 6.7±1.7 | 8.6±3.4 | <0.05 |
| Monocytes % | 7.2±2.4 | 6.5±2.1 | ns |
| Neutrophils % | 57.3±8.3 | 61.2±12.1 | <0.05 |
| Lymphocytes % | 30.4±7.1 | 27.1±9.3 | ns |
| Eosinophils % | 4.1±3.1 | 4.4±5.0 | ns |
| Basophils % | 0.7±0.8 | 0.7±0.8 | ns |
| Urinary mediators | |||
| Subjects n | 136 | 153 | |
| LTE4 ng·mmol−1 creatinine | 48±5.8 | 58±7.7# | <0.05 |
| EPX µg·mmol−1 creatinine | 45±4.6 | 62±9.3# | <0.05 |
| Exhaled NO | |||
| Subjects n | 45 | 50 | |
| Geometric mean ppb# (95% CI) | 9.2 (7.0–7.3) | 9.8 (7.3–13.2) | ns |
Data are presented as mean±sd unless otherwise indicated
WBC: white blood count
LTE4: leukotriene E4: EPX: eosinophil protein X
NO: nitric oxide
CI: confidence interval
#: age and sex adjusted