Table 1—

Indications for domiciliary ventilation in respiratory insufficiency

ConditionComments
Chest wall disorders RCTs unlikely: outcome without ventilatory support is death
Scoliosis
Thoracoplasty/previous TB procedures
Fibrothorax
Obesity hypoventilation syndrome
Neuromuscular disease RCTs unlikely: outcome without ventilatory support is death
Congenital
 Myopathies
 Duchenne muscular dystrophy
 Other muscular dystrophies
 Spinal muscular atrophy
 Hereditary sensory neuropathies, e.g. Charcot-Marie-Tooth disease
Acquired
 Old poliomyelitis
 Polymyositis
 Amyotrophic lateral sclerosis/motor neurone diseasePalliation of symptoms; may extend life
 Cervical spinal cord lesion
Neurological disorders
Congenital central hypoventilation syndrome
Brainstem cerebrovascular accident
Obstructive lung disease
Chronic obstructive pulmonary diseaseMixed results; further RCTs versus LTOT required
Idiopathic bronchiectasisRCTs versus LTOT required
Cystic fibrosisRCTs versus LTOT required
  • RCT: randomised controlled trial

  • TB: tuberculosis

  • LTOT: long-term oxygen therapy