Table 1

In vivo and in vitro mechanical parameters

ControlLPS596‐b596‐a
In vivo
 V′ mL·s−11.03±0.011.01±0.011.01±0.011.01±0.01
 V mL·s−10.21±0.010.21±0.010.20±0.010.20±0.01
 Est cmH2O·mL−126.27±1.2143.25±3.20*23.96±1.3324.60±1.33
 Edyn cmH2O·mL−129.88±1.2347.94±3.33*27.82±1.3728.31±1.36
 ΔE cmH2O·mL−13.61±0.164.70±0.18*3.86±0.173.71±0.13
 ΔPtot cmH2O1.21±0.041.60±0.06*1.21±0.041.17±0.03
 ΔP1 cmH2O0.47±0.020.63±0.03*0.46±0.010.41±0.01
 ΔP2 cmH2O0.74±0.040.97±0.04*0.75±0.030.75±0.02
In vitro
 E N·m−2·10−40.98±0.041.46±0.04*1.17±0.061.06±0.07
 R N·s−1·m−2·10−21.05±0.021.57±0.07*1.10±0.091.15±0.07
 η0.07±0.010.08±0.01*0.07±0.010.07±0.01

  • Data are presented as means±sem of six animals (10 determinations per mouse)

  • Data are shown for control, lipopolysaccharide (LPS), LASSBio596 1 h before LPS (596‐b) and LASSBio596 6 h after LPS (596‐a) groups

  • V′: gas flow

  • V: volume

  • Est: pulmonary static elastance

  • Edyn: pulmonary dynamic elastance

  • ΔE: difference between dynamic and static elastances

  • ΔPtot: total pressure

  • ΔP1: resistive pressure

  • ΔP2: viscoelastic/inhomogeneous pressure

  • E: tissue elastance

  • R: resistance

  • η: hysteresivity

  • *: p<0.05 versus the other groups