Inflammatory cell infiltration after the inhalation of cyclosporin (Cs)A alone in the airways of actively sensitised mice
| Group# | Number of cells in BALF ×105 | ||
| Macrophage | Eosinophil | Neutrophil | |
| No OA challenge | 6.6±0.7 | 0±0 | 0.1±0.0 |
| OA challenge | 6.4±0.9 | 1.6±0.4** | 1.5±0.6* |
| OA challenged at | |||
| 1 h after CsA¶ inhalation | 6.6±0.8 | 0.5±0.1 | 1.3±0.4 |
| 3 h after CsA¶ inhalation | 5.7±0.7 | 0.5±0.2 | 1.2±0.5 |
| 6 h after CsA¶ inhalation | 9.0±1.0 | 0.3±0.1+ | 2.2±0.7 |
| 12 h after CsA¶ inhalation | 5.7±0.6 | 0.4±0.1+ | 2.5±1.9 |
| 18 h after CsA¶ inhalation | 7.6±0.8 | 1.2±0.3 | 1.2±0.3 |
| 24 h after CsA¶ inhalation | 7.2±0.7 | 1.5±0.4 | 1.4±0.4 |
BALF: bronchoalveolar lavage fluid
#: n=6–8
¶: the exposed dose of CsA was calculated as 1325.5±21.7 µg·kg−1 in the airways
*: p<0.05
**: p<0.01 in comparison with the response of the untreated no ovalbumin (OA)-challenged group
+: p<0.05 in comparison with the response of the untreated OA-challenged group