Table 1

Subject characteristics

Severe COPDControl smokers
Subjects M:F8:312:1
Age yrs64±365±3
Smoking history
 Pack-yrs46±843±5
 Exsmokers n41
FEV1 % pred32±398±4
FEV1/FVC %36±375±2
Pa,O2 mmHg66±487±2**
Pa,CO2 mmHg44±438±1
KCO % pred40±777±10*
DL,CO % pred41±681±4**
  • Values are expressed as mean±sem

  • COPD: chronic obstructive pulmonary disease

  • M: male

  • F: female

  • FEV1: forced expiratory volume in one second

  • % pred: % predicted

  • FVC: forced vital capacity

  • Pa,O2: arterial oxygen tension

  • Pa,CO2: carbon dioxide arterial tension

  • KCO: carbon monoxide transfer coefficient

  • DL,CO: CO diffusing capacity

  • *: p<0.01

  • **: p<0.001 compared with severe COPD