Asthmatic | Nonasthmatic | p‐value | |
Subjects n | 25 | 18 | |
M:F | 14:11 | 5:13 | 0.12^{#} |
Age yrs | 46.5±5.9 | 33.7±5.6 | 0.001 |
Atopic | 21 (85%) | 7 (42%) | 0.006^{#} |
Exhaled NO ppb | 24.3 (17.2–34.4) | 12.4 (9.6–16.1) | 0.005 |
FEV_{1} % predicted | 83.3±5.7 | 99.4±5.3 | <0.001 |
R_{rs,mean} % predicted | 147.8±17.9 | 111.2±15.9 | 0. 007 |
Baseline tidal volume L | 0.91±0.09 | 0.86±0.09 | 0.45 |
Baseline inspiratory capacity L | 2.56±0.26 | 2.57±0.33 | 0.97 |
DRR % fall FEV_{1}·µmol^{−1} | 14.4 (8.6–22.9) | 0.26 (0.09–0.44) | <<0.001 |
Methacholine dose µmol | 1.8 (1.1–3.0) | 95.5 (54.7–166.6) | <<0.001 |
Increase in R_{rs,mean} % | 55.7±13.5 | 68.0±22.9 | 0.34 |
Decrease in FEV_{1} % | 24.4±2.4 | 15.0±3.0 | <0.001 |
Data are presented as mean±95% confidence interval (CI), geometric means (95% CI), or n (% positive skin-prick tests). p‐Values are for the comparison between groups by unpaired t‐test or Chi-squared test (^{#})
M: male
F: female
NO: nitric oxide
ppb: parts per billion
FEV_{1}: forced expiratory volume in one second
R_{rs,mean}: mean of all respiratory system resistance values obtained over 1 min of tidal breathing
DRR: dose-response ratio
<<: much less than