Table 1

Selected commonly used health-related quality-of-life instruments

Name	Items n, estimated time	Administration	Domains	Scale (worse–best); MID	Validity and reliability in patients with COPD
Generic instruments SIP	136, 20–30 min	Designed for either self or interviewer, telephone	12 Domains, two component scores, physical and psychosocial scores, five independent categories, one total score	0–100; MID unknown	Well documented, may not be discriminative with mild COPD
MOS, SF-36	36, 5–10 min	Self, interviewer, telephone	Eight domains	PCS, MCS; 0–100 Normalised to population mean±sd, 50±10. Domains; 0–100; MID five points	Valid and reproducible, responsiveness not well documented in COPD
NHP	50	Interviewer	Three domains: mobility, physical activity, social activity	0–1; MID unknown	Valid, reproducible, responsiveness not demonstrated
QWB	38, 10–15 min	Self	Six domains	100–0; MID unknown	Valid, reproducible, responsiveness not demonstrated
Disease-specific CRDQ	20, 20–30 min initial; 10–20 min repetitive	Designed primarily for interviewer; may be self-administered	Dyspnoea, emotional function, fatigue mastery	1–7 Likert scale; MID 0.5 per question for all domains	Well documented in multiple trials
SGRQ	76, 20 min	Self	Symptoms, activities, impact, overall score “no well-being”	100–0; MID four for all domains	Well documented in multiple trials
SOLDQ	29, 10–15 min	Self	Physical function, coping skills, emotional function, satisfaction	0–100; MID six for physical function domain	Documented in original description