Table 2—

Respiratory parameters measured at diagnosis and the follow-up visit

DiagnosisFollow-up
FVC % pred98.1±1.294.4±1.4§
FEV1 % pred98.8±1.698.1±1.7
FEV1/FVC ratio77.4±0.877.1±0.7
Airway obstruction#33.3%37.9%
FEV1/FVC <75%
PD20 mg0.466 (1.12)+1.042 (1.11)ƒ
  • FVC: forced vital capacity

  • FEV1: forced expiratory volume in one second

  • PD20: provocative dose of methacholine causing a 20% fall in FEV1

  • #: criteria from the American Thoracic Society

  • 1986 15; : predicted values from Commissions des Communautes Europeennes 16

  • +: geometric (G) mean and Gsem

  • §: significantly different from FVC (% pred) at diagnosis

  • by use of Mann-Whitney test

  • p<0.05

  • ƒ: significantly different from PD20 at diagnosis by use of Mann-Whitney test

  • p<0.001