Relationship between transition dyspnoea index (TDI) response and exacerbation over the study period/health status scores at end of study

	Total cohort		Native English countries TDI focal score 1		Nonnative English countries TDI focal score 1
	TDI R	TDI NR	TDI R	TDI NR	TDI R	TDI NR
Subjects n	382	615	135	252	247	363
Exacerbations
Patients with event %	29.8*	39.0	30.4**	41.7	29.6	37.2
Events per patient yr	0.872*	1.358	0.901**	1.399	0.857**	1.329
Health Status^#
SGRQ total score	−8.8±0.6**	0.9±0.5	−12.0±1.1*	−1.2±0.8	−7.0±0.8*	2.3±0.6
SGRQ impacts score	−7.7±0.3 **	1.3±0.6	−11.3±1.2*	−1.0±0.9	−5.9±0.9*	2.8±0.7
SGRQ symptom score	−13.6±1.2*	0.6±0.8	−18.3±1.9*	−3.1±1.3	−11.3±1.4*	3.1±1.1
SGRQ activity score	−7.7±0.8*	0.4±0.5	−9.6±1.2*	−0.4±0.9	−6.4±0.9*	0.99±0.7
Spirometry
Trough FEV₁	0.08±0.01*	0.01±0.01	0.13±0.02*	0.03±0.01	0.05±0.02 **	−0.01±0.01
Trough FVC	0.17±0.03*	0.05±0.02**	0.28±0.04*	0.11±0.03*	0.12±0.03*	0.01±0.03