Baseline | l‐NA | l‐NA+bosentan | ||||
Fi,O2 0.4 | Fi,O2 0.1 | Fi,O2 0.4 | Fi,O2 0.1 | Fi,O2 0.4 | Fi,O2 0.1 | |
Q′ L·min−1·m−2 | 3.3±0.3 | 3.4±0.3 | 3.2±0.3 | 3.2±0.3 | 3.1±0.3 | 3.3±0.3 |
Ppa mmHg | 12±1 | 18±2* | 19±2¶ | 27±3*,¶ | 18±2¶ | 22±3# |
Ppao mmHg | 4±1 | 3±1 | 10±2¶ | 6±1 | 8±1#,¶ | 5±1 |
Psa mmHg | 113±7 | 109±7 | 144±8¶ | 144±7¶ | 125±7#,¶ | 130±8#,¶ |
fc beats·min−1 | 149±8 | 157±8 | 115±6¶ | 145±8 | 121±7¶ | 145±8 |
pHa | 7.33±0.01 | 7.35±0.01 | 7.36±0.01 | 7.37±0.01 | 7.37±0.01 | 7.39±0.02 |
Pa,O2 mmHg | 195±12 | 36±1* | 201±7 | 35±1* | 160±14#,¶ | 32±2* |
Pa,CO2 mmHg | 37±1 | 33±1* | 35±1 | 34±1 | 34±1 | 33±2 |
Pv,O2 mmHg | 51±2 | 24±2* | 46±1 | 22±2* | 43±3¶ | 22±1* |
Data are presented as mean±sem
FI,O2: inspiratory oxygen fraction
Q′: cardiac index
Ppa: mean pulmonary artery pressure
Ppao: pulmonary artery occluded pressure
Psa: mean systemic artery pressure
fc: cardiac frequency
pHa: arterial pH
Pa,O2: oxygen tension in arterial blood
Pa,CO2: carbon dioxide tension in arterial blood
Pv,O2: oxygen tension in mixed venous blood
*: p<0.05 compared with FI,O2 0.4, same drug condition
#: p<0.05 compared with l‐NA, same FI,O2
¶: p<0.05 compared with baseline, same FI,O2