Fi,O2 | p‐value | ||||
0.4 | 0.21 | 0.12 | 0.1 | ||
Q′ L·min−1·m−2 | |||||
Baseline | 4.9±0.5 | 4.8±0.5 | 4.8±0.5 | 4.8±0.5 | ns |
Bosentan | 5.0±0.5 | 4.8±0.5 | 4.8±0.5 | 4.8±0.5 | ns |
Ppa mmHg | |||||
Baseline | 12±1 | 11±1 | 13±1 | 16±1 | <0.01 |
Bosentan | 11±1 | 11±1 | 13±1 | 15±1 | <0.01 |
Ppao mmHg | |||||
Baseline | 3±1 | 2±1 | 2±1 | 2±1 | ns |
Bosentan | 2±1 | 2±1 | 1±1 | 2±1 | ns |
Psa mmHg | |||||
Baseline | 109±10 | 114±12 | 123±15 | 122±17 | ns |
Bosentan | 105±9 | 104±14 | 108±14 | 104±11 | ns |
fc beats·min−1 | |||||
Baseline | 152±4 | 152±7 | 160±8 | 157±8 | ns |
Bosentan | 154±7 | 155±9 | 166±7 | 162±6 | ns |
pHa | |||||
Baseline | 7.32±0.03 | 7.33±0.01 | 7.35±0.01 | 7.34±0.02 | ns |
Bosentan | 7.34±0.01 | 7.34±0.02 | 7.36±0.02 | 7.37±0.02 | ns |
Pa,O2 mmHg | |||||
Baseline | 204±11 | 99±5 | 46±2 | 35±2 | <0.01 |
Bosentan | 213±16 | 98±8 | 47±4 | 35±3 | <0.01 |
Pa,CO2 mmHg | |||||
Baseline | 45±2 | 41±2 | 41±2 | 40±3 | ns |
Bosentan | 39±3 | 37±2 | 37±3 | 38±3 | ns |
Pv,O2 mmHg | |||||
Baseline | 62±4 | 51±3 | 32±2 | 26±2 | <0.01 |
Bosentan | 59±4 | 52±4 | 34±4 | 27±3 | <0.01 |
Data are presented as mean±sem
p‐value: level of significance of the F‐ratio of the analysis of variance
Q′: cardiac index
Ppa: mean pulmonary artery pressure
Ppao: pulmonary artery occluded pressure
Psa: mean systemic artery pressure
fc: cardiac frequency
pHa: arterial pH
Pa,O2: oxygen tension in arterial blood
Pa,CO2: carbon dioxide tension in arterial blood
Pv,O2: oxygen tension in mixed venous blood