Occupational exposure characteristics for high grade pre-invasive lesions (severe dysplasia or carcinoma in situ) relative to all lower grade lesions combined in 228 subjects in the early detection study
| Occupational exposure characteristics | No. subjects without/with high grade pre-invasive lesions | OR and p-value for Cochran's trend test when applicable | 95% CI |
| Asbestos exposure | |||
| No | 89/3 | 1.0 | |
| Yes | 118/18 | 4.5 | 1.3–15.8 |
| Duration of asbestos exposure yrs | |||
| No exposure | 89/3 | 1.0 | |
| ≤19 | 72/8 | 3.3 | 0.8–12.9 |
| ≥20 | 46/10 | 6.5 | 1.7–24.6 |
| p=0.004¶ | |||
| Latency of asbestos exposure yrs | |||
| No exposure | 89/3 | 1.0 | |
| ≤39 | 72/9 | 3.7 | 1.0–14.2 |
| ≥40 | 46/9 | 5.8 | 1.5–22.5 |
| p=0.008¶ | |||
| Delay since the end of asbestos exposure yrs | |||
| No exposure | 89/3 | 1.0 | |
| ≥10 | 84/9 | 3.2 | 0.8–12.1 |
| <10 | 34/9 | 7.9 | 2.0–30.7 |
| p=0.001¶ | |||
| Exposure to other occupational lung carcinogens (for >10 yrs) | |||
| No | 184/15 | 1.0 | |
| Yes | 23/6 | 3.2 | 1.1–9.0 |
Thirteen subjects who never smoked are not included (five with at most mild dysplasia, eight with moderate dysplasia)
¶: exact test was performed due to small sample size
OR: odds ratio
CI: confidence interval