Table 2—

Effect of treatment on numbers of inflammatory cells in bronchial biopsy samples

PlaceboSM50FP250
Neutrophils21.5 (0–127)14.3 (0–47)*18.4 (2–120)
EG111.8 (1–110)7.0 (0–187)5.5 (0–80)*
EG28.6 (2–197)6.6 (0–139)4.8 (0–40)
Mast cells19.3 (0–136)16.6 (0–191)13.7 (0–99)
CD377.9 (6–206)52.7 (27–140)56.5 (12–105)*
CD436.4 (5–94)30.2 (2–114)17.5 (3–47)*,**
CD45RO41.2 (3–162)32.3 (9–75)26.7 (3–63)*
  • Data are presented as median (range) number of cells per millimetre of reticular basement membrane. Treatment with salmeterol 50 µg powder b.d. (SM50) significantly reduced the numbers of neutrophils, whereas fluticasone propionate 250 µg powder b.d. (FP250) reduced numbers of eosinophils and lymphocytes compared with the placebo-treated group. EG: eosinophil granule

  • *: p<0.05 versus placebo

  • **: p<0.01 versus SM50