Comparison between children with preschool viral wheeze (PVW) after stratification for serum total immunoglobulin (Ig)E during an acute attack
| Serum total IgE | ||
| ≤95th percentile | >95th percentile | |
| Subjects n | 21 | 23 |
| Age months | 29 (17–38) | 38 (31–47) |
| Male:female | 13:8 | 19:4 |
| Eczema present n | 9 | 8 |
| Parental history of asthma n | 19 | 13 |
| First attack of PVW n | 4 | 4 |
| Previous PVW and no interval symptoms n | 12 | 14 |
| Previous PVW with interval symptoms n | 5 | 5 |
| Number of previous attacks of PVW n | 3 (2–7) | 5 (2–7) |
| uLTE4 during acute PVW ng·mM creatinine−1 | 150 (77–217) | 211 (118–312)* |
| Fall in uLTE4 on convalescence¶ ng·mM creatinine−1 | 34 (−93–160)+ | 84 (36–131)#,§ |
Data are presented as median (interquartile range) unless otherwise stated
uLTE4: urinary leukotriene E4
¶: mean (95% confidence interval)
+: n=5
§: n=14
The 95th percentile of IgE based on 14 (<3 yrs 74 kU·L−1, 3–5 yrs 87 kU·L−1)
*: p<0.05 versus normal controls by Mann-Whitney U‐test
#: p<0.05 versus acute levels by paired t‐test