Year | Treatment |
1950–1980 | Empirical/various vasodilators for acute vasoreactivity testing (tolazoline, acetylcholine, diazoxide, hydralazine, phentolamine, isoproterenol, nitrates, verapamil, nifedipine and diltiazem) |
1970–1980 | Uncontrolled trials on long-term vasodilator treatments |
1980– | Oral anticoagulants |
High-dose calciumchannel antagonists (in acute vasoreactivity tests responders) | |
Lung, heart/lung transplantation | |
1990– | Intravenous epoprostenol prostacyclin |
Balloon atrial septostomy | |
2000– | New compounds |