Reported excessive bronchoconstriction# (EB) caused by sputum induction in asthmatic subjects¶
| First author [Ref.] | Subjects n | Asthma chars | EB# n (%) | Induction procedure | Maximal fall in FEV1 | |||||||
| Baseline | Safety assessment | FEV1 % pred | sal % | Time min | Fall % | |||||||
| FEV1 % pred | Type | Interval min | Interruption | PreBD | PostBD | |||||||
| Pin 1 | 17 | Mild, stable | 1 (5.8) | 88.9 | FEV1 | 5.0 | fall ≥20%+ | NA | NA | NA | NA | 30 |
| Pizzichini 6 | 10 | exac | 4 (13.0) | 74.3 | FEV1 | 1–2 | fall ≥20%+,§ | NA | 93.0 | 3.0 | 3.0 | 42 |
| Wong 3 | 78 | Mildtomoderate | 11 (14.0) | >60.0 | FEV1 | 20 | fall ≥20%+ | 51.0 | 63.0 | 3.0 | 20 | 69 |
| Hunter 5 | 36 | Mild, stable | 3 (8.3) | 82.6 | FEV1 | 5.0 | fall ≥20%+ | NA | NA | NA | NA | 23 |
| VlachosMayer 14 | 304 | Mildtosevere | 24 (8.0) | 73.1 | FEV1 | 7 or 1–2 | fall ≥20%+,§ | 75.0 | NA | 5.0 | 21 | 50 |
| Pizzichini 34 | 31 | Mildtosevereƒ | 10 (32) | 73.9 | FEV1 | 7 or 1–2 | fall ≥20%+,§ | 67.5 | 77.5 | 3.0 | 7.0 | 53 |
chars: characteristics
EB: excessive bronchoconstriction
FEV1: forced expiratory volume in one second
% pred: percentage of the predicted value
BD: bronchodilator
PT: pretreatment
sal: saline
NA: not available
exac: exacerbation
#: as defined by a fall in FEV1 of ≥20%
¶: all subjects pretreated with bronchodilator (200 µg salbutamol)
+: or specimen obtained
§: or patient expiratory discomfort
ƒ: steroidnaive